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These agents pleotropic effects have translated into clinicals trials showing improvement in cardiovascular outcomes, improved quality of life and/or heart failure events in heart failure with preserved ejection fraction, resolution of steatohepatitis and improvement in liver fibrosis, prevention and treatment of type 2 diabetes, and improvement in renal function in chronic kidney disease
171 Treatment with ghrelin does not affect insulin secretion at 5.5mM glucose but significantly reduces it (by ~30%) at 16.8mM glucose
The lipid benefits observed with semaglutide appear to be largely mediated through weight reduction, though some direct effects on lipoprotein metabolism may also contribute
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